Yeah, one of the main side effects of Zoloft is reduced sex drive. Like the others said, most SSRI's can be that way. I'm on Zoloft though and while I do notice a difference in my sex drive, it's not affecting my life so much that I feel like I need to switch meds. Mostly because this one is finally working for my depression. Anyway, if you were to start taking Zoloft and notice a change in sex drive that you really didn't want to experience, you could always discuss changing meds with your doctor. Sorry for rambling..hope I helped.